Open AccessDyslipidemia as Predictor of Missed Miscarriage
Author(s) -
А. А. Оразмурадов,
Sergey G. Morozov,
Anastasiya Akhmatova,
Khalid Haddad,
А. В. Лопатин,
Fatima Ramazanova,
Irina Bekbaeva,
Sergey Kyrtikov,
Zhasmina Z. Suleymanova,
Aleksey Lukaev
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(4)_oa4
Subject(s) - dyslipidemia , miscarriage , medicine , gestation , serology , pregnancy , obstetrics , gestational age , gynecology , physiology , immunology , antibody , biology , genetics , obesity
Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2. Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia.