Open AccessGlutathione-Dependent Mechanisms of Antioxidant Defense in Men with Pathozoospermia after COVID-19 Infection
Author(s) -
Н. А. Курашова,
Б. Г. Дашиев,
Lyubov Kolesnikova
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(4)_oa23
Subject(s) - glutathione , covid-19 , antioxidant , redox , cell , enzyme , chemistry , immunology , biology , biochemistry , medicine , disease , organic chemistry , infectious disease (medical specialty)
The article presents results of studying the influence of COVID-19 infections on glutathione metabolism in men with pathozoospermia and COVID-19. In erythrocyte cytolysate, we determined concentration of reduced (GSH) and oxidized (GSSG) glutathione and the GSH/GSSG ratio as the main indication of cell redox-status and an important factor in cell redox-dependent signaling control along with the effect GSH-dependent enzymes. Results of our study allowed us to determine the peculiarity of the influence of COVID-19 infection on thee glutathione metabolic pathway. The understanding of the influence mechanisms of SARS-CoV-2 on metabolic processes in the body of men with pathozoospermia has been expanded. The data obtained give grounds and opportunities for a more reasonable approach to the organization of preventive, curative, and rehabilitative measures for COVID-19 infection.