Glutathione-Dependent Mechanisms of Antioxidant Defense in Men with Pathozoospermia after COVID-19 Infection | Zendy

Н. А. Курашова | Zendy; Б. Г. Дашиев | Zendy; Lyubov Kolesnikova | Zendy

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Glutathione-Dependent Mechanisms of Antioxidant Defense in Men with Pathozoospermia after COVID-19 Infection

Author(s) -

Н. А. Курашова,

Б. Г. Дашиев,

Lyubov Kolesnikova

Publication year - 2021

Publication title -

international journal of biomedicine

Language(s) - English

Resource type - Journals

eISSN - 2158-0529

pISSN - 2158-0510

DOI - 10.21103/article11(4)_oa23

Subject(s) - glutathione , covid-19 , antioxidant , redox , cell , enzyme , chemistry , immunology , biology , biochemistry , medicine , disease , organic chemistry , infectious disease (medical specialty)

The article presents results of studying the influence of COVID-19 infections on glutathione metabolism in men with pathozoospermia and COVID-19. In erythrocyte cytolysate, we determined concentration of reduced (GSH) and oxidized (GSSG) glutathione and the GSH/GSSG ratio as the main indication of cell redox-status and an important factor in cell redox-dependent signaling control along with the effect GSH-dependent enzymes. Results of our study allowed us to determine the peculiarity of the influence of COVID-19 infection on thee glutathione metabolic pathway. The understanding of the influence mechanisms of SARS-CoV-2 on metabolic processes in the body of men with pathozoospermia has been expanded. The data obtained give grounds and opportunities for a more reasonable approach to the organization of preventive, curative, and rehabilitative measures for COVID-19 infection.

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