Open AccessMolecular Predictors of Effective Implantation and Live Birth in IVF Programs
Author(s) -
Elena Chukhnina,
Е. Л. Казачков,
Е. Л. Воропаева,
Ella Kazachkova,
Miroslava Polina,
N.I. Douglas
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(4)_oa21
Subject(s) - infertility , endometrium , stromal cell , calcitriol receptor , gynecology , andrology , live birth , medicine , blastocyst , immunohistochemistry , pregnancy , obstetrics , biology , vitamin d and neurology , embryo , embryogenesis , genetics , microbiology and biotechnology
The aim of the study was to improve the possibilities of predicting blastocyst implantation and live birth of ART programs in women of late reproductive age with tubal-peritoneal infertility based on immunohistochemical markers of the endometrium. Methods and Results: The results of IVF and IVF/ICSI programs were analyzed in 68 patients of late reproductive age (36-44 years of age) with tubal-peritoneal factor of infertility. Morphological examination of the endometrium was performed on Day 7 after confirmed ovulation in the cycle preceding ART. The expression of vitamin D receptors (VDR) and HOXA11 in endometrial stromal cells was assessed by immunohistochemical method. The effectiveness of using the endometrial markers VDR and HOXA11 as potential predictors of ART programs efficiency was confirmed by prognostic models. The levels of the stromal expression of VDR 0.27) were determined to be favorable for successful blastocyst implantation. The expression levels of VDR 0.19) in women of late reproductive age with tubal-peritoneal infertility who undergoing ART treatment with their own oocytes.