Open AccessBone Marrow Adipocytes and Hematology: A Literature Review
Author(s) -
Н. А. Кривенцова,
А. М. Шестопалов,
Galina Tereshchenko
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(2)_ra2
Subject(s) - haematopoiesis , bone marrow , aplastic anemia , multiple myeloma , hematology , leukemia , endocrine system , cancer research , medicine , immunology , endocrinology , biology , stem cell , microbiology and biotechnology , hormone
This review focuses on the impact of bone marrow adipocytes on hematopoiesis and the development of hematological diseases. Bone marrow fat is a metabolically active organ capable of accumulating energy required for active hematopoiesis as well as of performing endocrine functions and participating in bone formation. Adipocytes can interact with the surrounding cells both directly and indirectly via cytokines and chemokines. Apart from their active involvement in the normal hematopoiesis, BMA have also been shown to play an important role in such diseases as leukemia, multiple myeloma and aplastic anemia. The role of fat cells in hematopoiesis is still unclear and not well studied, yet it is undoubtedly important, as demonstrated by the ever increasing number of publications supporting this conclusion.