Open AccessAssociation of Polymorphisms in PPARPGC1A, ACE, and DRD2 Genes with Gestational Diabetes Mellitus
Author(s) -
А. А. Оразмурадов,
Irina Bekbaeva,
Gayane Arakelyan,
М.Z. Аbitova,
Khalid Haddad,
А. В. Лопатин,
Sergey Kyrtikov,
Gulnoza Eldashova,
Ekaterina Mukovnikova,
Aleksey Lukaev
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(1)_oa8
Subject(s) - gestational diabetes , medicine , snp , endocrinology , genotype , single nucleotide polymorphism , pregnancy , gestation , biology , genetics , gene
The aim of our research was to study the distribution of polymorphic variants of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D in gestational diabetes mellitus (GDM). Methods and Results: The study included 383 pregnant women (gestational age of 37.0–41.0 weeks) with GDM and 68 pregnant women without disturbed carbohydrate metabolism. This was a prospective case-control study. All patients were divided into 3 groups. Group 1 included 211 pregnant women with GDM who received diet therapy only; Group 2 included 172 pregnant women with GDM who received insulin therapy; Group 3 included 68 pregnant women without metabolic disorders. For the DRD2/ANKK1 TaqIA (rs1800497 SNP) (A1/A2; T/C), we found that the TT homozygous genotype and T allele prevailed in Groups with GDM compared with Group without metabolic disorders. Conclusion: A study of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D revealed statistically significant increased risks for GDM in carriers of the TT genotype and T allele of the DRD2/ANKK1 TaqIA (rs1800497 SNP).