Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker

Objective: In pharmacotherapy, factors such as mode of administration, dose, and contraindications play a significant part in determining the optimal pharmacotherapeutic strategy. A drug’s ability to influence the safety or efficacy of another drug (drug-drug interaction) is another factor to consider when choosing the best pharmacotherapy [1]. When multiple medications are prescribed at the same time, they may interact [2]. Drug-drug interactions (DDIs) can have a variety of outcomes, and adverse DDIs might result in patient death or drug withdrawal. Drug interactions can alter the pharmacokinetics and/or harmacodynamics of a drug which may leads to therapeutic failure or any adverse drug event. Co-administration of naproxen with losartan will decrease the action of losartan which is an anti-hypertensive agent leads to uncontrolled hypertension. NSAIDs inhibit prostaglandin thus antagonise effect of converting enzyme inhibitors. Losartan is angiotensin receptor blocker, whose natriuretic effects decreased by naproxen. Keywords: Drug-drug interaction, Pharmacotherapy, Tertiary care hospital, Naproxen, Losartan, Clinical pharmacy