Open AccessRare Transformation of Chronic Myeloid Leukemia into Acute Lymphoblastic Leukemia in a 14-Year Old Patient
Author(s) -
Javera Tariq,
Sundas Ali,
Shahzad Ali Jiskani,
Rabiah Asghar
Publication year - 2020
Publication title -
national journal of health sciences
Language(s) - English
Resource type - Journals
eISSN - 2519-7878
pISSN - 2519-7053
DOI - 10.21089/njhs.52.0086
Subject(s) - medicine , myeloid leukemia , myeloproliferative neoplasm , lymphoblastic leukemia , incidence (geometry) , myeloid , disease , leukemia , pediatrics , bone marrow , myelofibrosis , physics , optics
Chronic myeloid leukemia is a myeloproliferative neoplasm. It is a common disease of elderly, rarely affecting pediatric, adolescent or young adults. The median age of presentation is 65 years. The incidence is 1‐2 cases per 100,000 adults. Tyrosine kinase inhibitors (TKIs) are highly successful and have good remission rates in the CML treatment; though multiple factors are associated with failure of treatment. We present a patient of 14 years old male who was diagnosed as CML. He was seven months into TKI therapy, transformed into B-Lineage acute lymphoblastic leukemia. Keywords: Chronic myeloid leukemia, Rare, Acute lymphoblastic leukemia, Pediatric, Transformation.