Open AccessAcute Leukemia of Ambiguous Lineage with a Rare Abnormality Del17p by FISH Analysis
Author(s) -
Naeem Abbas,
Samra Waheed,
Aisha Jamal,
Ali Faisal Saleem,
Tahir Shamsi
Publication year - 2020
Publication title -
national journal of health sciences
Language(s) - English
Resource type - Journals
eISSN - 2519-7878
pISSN - 2519-7053
DOI - 10.21089/njhs.52.0079
Subject(s) - acute leukemia , myeloid leukemia , leukemia , lineage (genetic) , medicine , karyotype , transplantation , hematopathology , fluorescence in situ hybridization , abnormality , oncology , pathology , cytogenetics , biology , genetics , chromosome , gene , psychiatry
The World Health Organization (WHO) has categorized acute undifferentiated leukemia (AUL) as a rare subtype of acute leukemia of ambiguous lineage (ALAL). The prognosis of AUL is considered poor and it expresses no known lineage-specific markers. In majority of the cases, AUL has been associated with karyotypic abnormalities, most commonly deletion 5q and complex karyotype. Deletion 17p correlation with acute myeloid leukemia and myelodysplastic syndome has been previously established and is associated with poorer outcomes. Herein we are reporting a case of forty years old male who was referred to National institute of blood diseases and bone marrow transplantation with complains of fever, multiple neck swellings, and early satiety and was diagnosed as Acute Undifferentiated Leukemia along with deletion 17p. This is a rare entity and can aid in further diagnostic and therapeutic approaches. Keywords: Acute undifferentiated leukemia, Deletion 17p, Flourescnece in situ hybridization, Allogeneic haematopoetic stem cell transplantation, Flow cytometry.