INFLUENCE OF HYPERGLYCEMIA ON OXIDATIVE STRESS AND DNAase-MEDIATED GENOMIC FRAGMENTATION COUPLED WITH APOPTOTIC AND NECROTIC CELL DEATHS IN KIDNEY | Zendy

Mohammed Saleem | Zendy

Open Access

INFLUENCE OF HYPERGLYCEMIA ON OXIDATIVE STRESS AND DNAase-MEDIATED GENOMIC FRAGMENTATION COUPLED WITH APOPTOTIC AND NECROTIC CELL DEATHS IN KIDNEY

Author(s) -

Mohammed Saleem

Publication year - 2011

Publication title -

canadian journal of applied sciences

Language(s) - English

Resource type - Journals

ISSN - 1925-7430

DOI - 10.21065/19257430.129.1

Subject(s) - dna fragmentation , oxidative stress , fragmentation (computing) , nephrotoxicity , apoptosis , reactive oxygen species , chemistry , kidney , antipyretic , analgesic , prostaglandin , pharmacology , programmed cell death , biology , biochemistry , endocrinology , ecology

Diclofenac (DCLF) is a potent inhibitor of prostaglandin synthesis and an established antipyretic and analgesic agent. It also has a nephrotoxic profile caused by generation of reactive oxygen species and enhanced apoptotic DNA fragmentation. The specific goals of this investigation were to determine

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