Open AccessINFLUENCE OF HYPERGLYCEMIA ON OXIDATIVE STRESS AND DNAase-MEDIATED GENOMIC FRAGMENTATION COUPLED WITH APOPTOTIC AND NECROTIC CELL DEATHS IN KIDNEY
Author(s) -
Mohammed Saleem,
AUTHOR_ID
Publication year - 2011
Publication title -
canadian journal of applied sciences
Language(s) - English
Resource type - Journals
ISSN - 1925-7430
DOI - 10.21065/19257430.129.1
Subject(s) - oxidative stress , dna fragmentation , apoptosis , fragmentation (computing) , nephrotoxicity , reactive oxygen species , diclofenac , chemistry , antipyretic , analgesic , pharmacology , kidney , programmed cell death , cancer research , medicine , biology , biochemistry , endocrinology , ecology
Diclofenac (DCLF) is a potent inhibitor of prostaglandin synthesis and an established antipyretic and analgesic agent. It also has a nephrotoxic profile caused by generation of reactive oxygen species and enhanced apoptotic DNA fragmentation. The specific goals of this investigation were to determine