Development of a Murine Model of Pyogenic Flexor Tenosynovitis | Zendy

Bowen Qiu | Zendy; Justin Cobb | Zendy; Alayna E. Loiselle | Zendy; Constantinos Ketonis | Zendy

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Development of a Murine Model of Pyogenic Flexor Tenosynovitis

Author(s) -

Bowen Qiu,

Justin Cobb,

Alayna E. Loiselle,

Constantinos Ketonis

Publication year - 2021

Publication title -

journal of bone and joint surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.634

H-Index - 260

eISSN - 1058-2436

pISSN - 0021-9355

DOI - 10.2106/jbjs.20.00428

Subject(s) - medicine , pathology , in vivo , tenosynovitis , bioluminescence imaging , surgery , andrology , biology , luciferase , transfection , genetics , microbiology and biotechnology , cell culture

Pyogenic flexor tenosynovitis is a debilitating infection of the hand flexor tendon sheath with high morbidity despite standard treatments of empiric antibiotics with irrigation and debridement. In vivo studies in the available literature have used avian models, but these models are difficult to scale and maintain. The purpose of this study was to demonstrate the plausibility of a murine model of pyogenic flexor tenosynovitis utilizing bioluminescence imaging and tissue analysis at harvest.

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