Open AccessLack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis
Author(s) -
Stephen L. Kates,
John R. Owen,
Christopher A. Beck,
Chao Xie,
Gowrishankar Muthukrishnan,
John L. Daiss,
Edward M. Schwarz
Publication year - 2020
Publication title -
journal of bone and joint surgery. american volume/the journal of bone and joint surgery. american volume
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 260
eISSN - 1058-2436
pISSN - 0021-9355
DOI - 10.2106/jbjs.20.00029
Subject(s) - medicine , staphylococcus aureus , osteomyelitis , incidence (geometry) , adverse effect , diabetes mellitus , antibody , sepsis , antibody titer , odds ratio , immunity , immunology , surgery , gastroenterology , titer , immune system , biology , endocrinology , genetics , physics , bacteria , optics
Glucosaminidase (Gmd) is known to be a protective antigen in animal models of Staphylococcus aureus osteomyelitis. We compared the endogenous anti-Gmd antibody levels in sera of patients with culture-confirmed S. aureus bone infections to their sera at 1 year after operative treatment of the infection.