Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis | Zendy

Stephen L. Kates | Zendy; John R. Owen | Zendy; Christopher A. Beck | Zendy; Chao Xie | Zendy; Gowrishankar Muthukrishnan | Zendy; John L. Daiss | Zendy; Edward M. Schwarz | Zendy

Open Access

Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis

Author(s) -

Stephen L. Kates,

John R. Owen,

Christopher A. Beck,

Chao Xie,

Gowrishankar Muthukrishnan,

John L. Daiss,

Edward M. Schwarz

Publication year - 2020

Publication title -

journal of bone and joint surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.634

H-Index - 260

eISSN - 1058-2436

pISSN - 0021-9355

DOI - 10.2106/jbjs.20.00029

Subject(s) - medicine , staphylococcus aureus , osteomyelitis , incidence (geometry) , adverse effect , diabetes mellitus , antibody , sepsis , antibody titer , odds ratio , immunity , immunology , surgery , gastroenterology , titer , immune system , biology , endocrinology , genetics , physics , bacteria , optics

Glucosaminidase (Gmd) is known to be a protective antigen in animal models of Staphylococcus aureus osteomyelitis. We compared the endogenous anti-Gmd antibody levels in sera of patients with culture-confirmed S. aureus bone infections to their sera at 1 year after operative treatment of the infection.

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