Open AccessPPARGC1B Is Associated with Nontraumatic Osteonecrosis of the Femoral Head
Author(s) -
Yanfei Zhang,
Thomas R. Bowen,
Steven A. Lietman,
Michael Suk,
Marc S. Williams,
Ming Ta Michael Lee
Publication year - 2020
Publication title -
journal of bone and joint surgery. american volume/the journal of bone and joint surgery. american volume
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 260
eISSN - 1058-2436
pISSN - 0021-9355
DOI - 10.2106/jbjs.19.01335
Subject(s) - medicine , femoral head , odds ratio , confidence interval , genome wide association study , single nucleotide polymorphism , oncology , bioinformatics , surgery , genotype , gene , genetics , biology
Previous studies have demonstrated the influence of heritable factors on the development of nontraumatic osteonecrosis of the femoral head (ONFH). We hypothesized that genetic variation is associated with an increased risk of ONFH, and that variants could be identified by a genomewide association study (GWAS).