Open AccessMice as Animal Model for Evaluation of Therapeutic Efficacy of Preparations against Monkeypox
Author(s) -
А. А. Сергеев,
А. С. Кабанов,
Bulychev Le,
Oleg V. Pyankov,
А. Н. Сергеев,
О. С. Таранов,
С. А. Боднев,
Ю. В. Туманов,
Л. Н. Шишкина,
А. П. Агафонов,
А. Н. Сергеев
Publication year - 2013
Publication title -
problemy osobo opasnyh infekcij
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 3
eISSN - 2658-719X
pISSN - 0370-1069
DOI - 10.21055/0370-1069-2013-2-60-65
Subject(s) - monkeypox , smallpox , body weight , virology , medicine , animal model , pharmacology , immunology , biology , vaccinia , vaccination , biochemistry , gene , recombinant dna
of MPV after 7 days postinfection, applying peroral administration once within 24 hours (24 hours before infection and 7 days after infection of mouse with 60 µg/g of a preparation). Displayed is the feasibility of using 8–15-days-old ICR mice (body weight 9–11 g) as an animal model for evaluation of therapeutic efficacy of the preparations under development against Monkeypox and smallpox.