Open AccessQualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation
Author(s) -
Д. А. Будыка,
A. I. Bondarenko,
А. А. Фисун,
Н. В. Абзаева,
Г. Ф. Иванова,
С. Е. Гостищева,
S. M. Rudnev
Publication year - 2012
Publication title -
problemy osobo opasnyh infekcij
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 3
eISSN - 2658-719X
pISSN - 0370-1069
DOI - 10.21055/0370-1069-2012-4-33-35
Subject(s) - yersinia pestis , plague (disease) , microbiology and biotechnology , sublimation (psychology) , strain (injury) , biology , virology , materials science , genetics , virulence , gene , medicine , psychology , pathology , anatomy , psychotherapist
The preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been proposed. This interpretation stipulates a smaller damaging effect of steam molecules during sublimation in the process of lyophilization.