Open AccessImmunobiological Characteristics of Cholera Toxin B-Subunit
Author(s) -
С. Н. Клюева,
Т. Н. Щуковская,
Т П Шмелькова,
А. Л. Кравцов,
С. А. Бугоркова,
Н. И. Смирнова,
О. А. Волох,
Taisiya Zakharova,
N. I. Belyakova,
Sergei A. Eremin,
А. К. Никифоров
Publication year - 2012
Publication title -
problemy osobo opasnyh infekcij
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 3
eISSN - 2658-719X
pISSN - 0370-1069
DOI - 10.21055/0370-1069-2012-3-67-70
Subject(s) - cholera toxin , toxin , protein subunit , cholera , antibody , microbiology and biotechnology , biology , virology , antiserum , immunology , biochemistry , gene
Carried out was immunobiological evaluation of cholera toxin B subunit preparations obtained using different experimental and production methods. It was demonstrated that B subunit preparations were non-toxic for biomodels and did not cause significant pathological alterations in their organs and tissues. They also did not alter the condition of immunocompetent cells at different stages of their cycle, and promote anti-toxic antibodies production. Thus, B subunit preparations under study can be considered as promising components of cholera vaccine.