Open AccessBactericidal Activity of Polymorphonuclear Blood Leucocytes of White Mice Vaccinated Against Plague and in Different Schemes of Introduction of Plague Infection
Author(s) -
Д. А. Будыка,
Н. В. Абзаева,
S. M. Rudnev,
Г. Ф. Иванова,
А. А. Фисун,
С. Е. Гостищева,
A. I. Bondarenko
Publication year - 2009
Publication title -
problemy osobo opasnyh infekcij
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 3
eISSN - 2658-719X
pISSN - 0370-1069
DOI - 10.21055/0370-1069-2009-2(100)-56-60
Subject(s) - plague (disease) , myeloperoxidase , microbiology and biotechnology , yersinia pestis , white blood cell , biology , immunology , virology , chemistry , medicine , virulence , inflammation , biochemistry , pathology , gene
Investigated was dynamics of germicidal activity factors (cationic proteins and myeloperoxidase) in polymorphonuclear leucocytes (PMNL) of peripheral blood of white mice immunized against plague and in the course of plague infection in different modifications of infectious process. Plague resistance in white mice was shown to correlate with PMNL protective function, the latter being provided mainly by myeloperoxidase system supported by cationic proteins system. The alteration of activity level of myeloperoxidase and cationic proteins in PMNL may be considered as indirect index of white mice plague resistance.