Open AccessCirc-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression
Author(s) -
Yuanyong Wang,
Rongjian Xu,
Dongyang Zhang,
Tong Lu,
Wanpeng Yu,
Yang Wo,
Ao Liu,
Tianyi Sui,
Jian Cui,
Yi Qin,
Yanting Dong,
Xiaoliang Leng,
Dezhi Kong,
Weihua Du,
Zhangfeng Huang,
Weiwei Su,
Tianxiang Yuan,
Xiao Sun,
Jianxun Wang,
Wenjie Jiao
Publication year - 2019
Publication title -
translational lung cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 41
eISSN - 2226-4477
pISSN - 2218-6751
DOI - 10.21037/tlcr.2019.11.04
Subject(s) - microrna , carcinogenesis , cell growth , cancer research , lung cancer , circular rna , competing endogenous rna , in vivo , rna , luciferase , signal transduction , cell culture , mapk/erk pathway , biology , microbiology and biotechnology , cancer , long non coding rna , medicine , gene , transfection , oncology , genetics
Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays a key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven to be a tumor-dependent circRNA. However, its role in non-small cell lung cancer (NSCLC) has been underreported.