Open AccessPrognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer
Author(s) -
Yingqin Wang,
Yaxing Shen,
Xia Sun,
Tinah L. Hong,
Long Shuang Huang,
Ming Zhong
Publication year - 2019
Publication title -
translational lung cancer research
Language(s) - English
Resource type - Journals
eISSN - 2226-4477
pISSN - 2218-6751
DOI - 10.21037/tlcr.2019.10.04
Subject(s) - sphingosine 1 phosphate , sphingosine , enzyme , medicine , lung cancer , cancer research , metabolism , cell metabolism , cancer , cell , bioinformatics , biochemistry , biology , receptor
Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes in S1P metabolism were associated with clinical outcomes in patients with NSCLC. Nevertheless, the roles of mRNA expression of major enzymes ( SPHK1 , SPHK2 and SGPL1 ) in S1P metabolism for predicting outcomes in NSCLC patients have not been determined.