Open AccessValidation of a serum 4-microRNA signature for the detection of lung cancer
Author(s) -
Xia Yang,
Wenmei Su,
Xiuyuan Chen,
Qing Geng,
Jingyi Zhai,
Shan Huang,
Chunfang Guo,
Zhuwen Wang,
Han Fu,
Hui Jiang,
Jules Lin,
Kiran H. Lagisetty,
Jie Zhang,
Yali Li,
Shuanying Yang,
Pierre P. Massion,
David G. Beer,
Andrew C. Chang,
Nithya Ramnath,
Guoan Chen
Publication year - 2019
Publication title -
translational lung cancer research
Language(s) - English
Resource type - Journals
eISSN - 2226-4477
pISSN - 2218-6751
DOI - 10.21037/tlcr.2019.09.11
Subject(s) - receiver operating characteristic , medicine , microrna , logistic regression , lung cancer , confidence interval , oncology , biomarker , cancer , bioinformatics , gene , biology , genetics
Our previous studies have identified a serum-based 4-microRNA (4-miRNA) signature that may help distinguish patients with lung cancer (LC) from non-cancer controls (NCs). Here, we used an extended independent cohort of 398 subjects to further validate the diagnostic ability of this 4-miRNA signature.