Open AccessMUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors
Author(s) -
Ying Chen,
Yunchao Huang,
Madiha Kanwal,
Guangjian Li,
Jiapeng Yang,
Huatao Niu,
Zhenhui Li,
Xiaojie Ding
Publication year - 2019
Publication title -
translational lung cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 41
eISSN - 2226-4477
pISSN - 2218-6751
DOI - 10.21037/tlcr.2019.07.10
Subject(s) - lung cancer , medicine , lung , population , metastasis , cancer , cell , cancer research , carcinogen , pathology , oncology , immunology , biology , genetics , environmental health
Inherited susceptibility and environmental carcinogens are crucial players in lung cancer etiology, and both exhibit population heterogeneity. MUC16 is overexpressed in various cancers and often associated with poor prognosis. Present work was to investigate the clinical significance of MUC16 in non-small cell lung cancer patients affected by familial lung cancer (FLC) and indoor air pollution caused by coal use.