Open AccessCircular RNAs and competing endogenous RNA (ceRNA) networks
Author(s) -
Apratim Mitra,
Karl Pfeifer,
Ki-Sun Park
Publication year - 2018
Publication title -
translational cancer research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 2219-6803
pISSN - 2218-676X
DOI - 10.21037/tcr.2018.05.12
Subject(s) - competing endogenous rna , biology , microrna , endogeny , computational biology , circular rna , rna , long non coding rna , gene , bioinformatics , genetics , endocrinology
In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance. Especially, investigators have begun focusing on the possibility that circRNAs operate as part of competing endogenous RNA (ceRNA) regulatory networks that are proposed to play critical roles in normal development and in pathologic conditions like cancer.