Open AccessMatrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Author(s) -
Amber M. Bates,
Maria Paula Gomez Hernandez,
Emily A. Lanzel,
Fang Qian,
Kim A. Brogden
Publication year - 2018
Publication title -
translational cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 2219-6803
pISSN - 2218-676X
DOI - 10.21037/tcr.2018.05.09
Subject(s) - head and neck squamous cell carcinoma , mmp1 , cancer research , cell culture , matrix metalloproteinase , biomarker , biology , cancer , chemistry , medicine , head and neck cancer , biochemistry , gene expression , genetics , gene
Biomarkers like programmed death ligand-1 (PDL1) have become a focal point for immunotherapeutic checkpoint inhibition in head and neck squamous cell carcinoma (HNSCC). However, it's only part of the total immunosuppressive biomarker profile of HNSCC cells. Matrix metalloproteinases (MMPs) are enzymes that break down the basement membrane allowing cancer cells to metastasize and play an important role in the tumor microenvironment. MMPs can also activate certain cytokines, growth factors, and chemokines post-translationally. The objective of this study was to determine MMP and biomarker profiles of seven different HNSCC cell lines.