Therapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors | Zendy

Mounsif Azizi | Zendy; Ahmet M. Aydin | Zendy; Salim Cheriyan | Zendy; Charles C. Peyton | Zendy; Matthew Montanarella | Zendy; Scott M. Gilbert | Zendy; Wade J. Sexton | Zendy

Open Access

Therapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors

Author(s) -

Mounsif Azizi,

Ahmet M. Aydin,

Salim Cheriyan,

Charles C. Peyton,

Matthew Montanarella,

Scott M. Gilbert,

Wade J. Sexton

Publication year - 2020

Publication title -

translational andrology and urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.721

H-Index - 27

eISSN - 2223-4691

pISSN - 2223-4683

DOI - 10.21037/tau.2019.09.08

Subject(s) - malignancy , malignant transformation , medicine , stromal cell , testicular cancer , cancer , teratoma , pathology , somatic cell , oncology , biology , biochemistry , gene

Testicular cancer is the most common solid malignancy in male adolescents and young adults, with germ cell derived seminomas and non-seminomas being by far the most common histologies. Teratoma with somatic-type malignancy is a rare chemo-resistant phenotype of testis cancer associated with poor prognosis in patients with advanced stage disease. Malignant gonadal-stromal tumors comprise 5% of testicular neoplasms and approximately 10% are malignant and considered chemo-radiation resistant. Prognostic factors and treatment strategies for these uncommon histologies are lacking.

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