Open AccessTherapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors
Author(s) -
Mounsif Azizi,
Ahmet Aydın,
Salim Cheriyan,
Charles C. Peyton,
Matthew Montanarella,
Scott M. Gilbert,
Wade J. Sexton
Publication year - 2020
Publication title -
translational andrology and urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.721
H-Index - 27
eISSN - 2223-4691
pISSN - 2223-4683
DOI - 10.21037/tau.2019.09.08
Subject(s) - malignancy , medicine , malignant transformation , testicular cancer , stromal cell , somatic cell , oncology , cancer , pathology , cancer research , biology , biochemistry , gene
Testicular cancer is the most common solid malignancy in male adolescents and young adults, with germ cell derived seminomas and non-seminomas being by far the most common histologies. Teratoma with somatic-type malignancy is a rare chemo-resistant phenotype of testis cancer associated with poor prognosis in patients with advanced stage disease. Malignant gonadal-stromal tumors comprise 5% of testicular neoplasms and approximately 10% are malignant and considered chemo-radiation resistant. Prognostic factors and treatment strategies for these uncommon histologies are lacking.