The effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle | Zendy

Hongyi Yang | Zendy; Gang Li | Zendy; Haixia Jin | Zendy; Yihong Guo | Zendy; Yingpu Sun | Zendy

Open Access

The effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle

Author(s) -

Hongyi Yang,

Gang Li,

Haixia Jin,

Yihong Guo,

Yingpu Sun

Publication year - 2019

Publication title -

translational andrology and urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.721

H-Index - 27

eISSN - 2223-4691

pISSN - 2223-4683

DOI - 10.21037/tau.2019.06.22

Subject(s) - sperm , assisted reproductive technology , dna fragmentation , intracytoplasmic sperm injection , in vitro fertilisation , human fertilization , andrology , gynecology , fertility , insemination , pregnancy , sperm washing , semen , biology , medicine , obstetrics , infertility , population , genetics , apoptosis , environmental health , programmed cell death

The sperm DNA fragmentation index (DFI) is widely regarded as a key measure for assessing male fertility, but the predictive value of the DFI for outcomes of assisted reproductive technology (ART) remains under debate. In this study, we used a large sample to analyze the effect of sperm DFI on pregnancy outcomes following ART and its relationship with oocyte fertilization and embryo development in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). We also explore the value of sperm DNA fragmentation (SDF) and its associated factors in assessing male fertility.

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