Open AccessThe effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle
Author(s) -
Hongyi Yang,
Gang Li,
Haixia Jin,
Yanjie Guo,
Yingpu Sun
Publication year - 2019
Publication title -
translational andrology and urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.721
H-Index - 27
eISSN - 2223-4691
pISSN - 2223-4683
DOI - 10.21037/tau.2019.06.22
Subject(s) - sperm , assisted reproductive technology , dna fragmentation , intracytoplasmic sperm injection , in vitro fertilisation , human fertilization , andrology , gynecology , fertility , insemination , pregnancy , sperm washing , semen , biology , medicine , obstetrics , infertility , population , genetics , apoptosis , environmental health , programmed cell death
The sperm DNA fragmentation index (DFI) is widely regarded as a key measure for assessing male fertility, but the predictive value of the DFI for outcomes of assisted reproductive technology (ART) remains under debate. In this study, we used a large sample to analyze the effect of sperm DFI on pregnancy outcomes following ART and its relationship with oocyte fertilization and embryo development in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). We also explore the value of sperm DNA fragmentation (SDF) and its associated factors in assessing male fertility.