Open AccessEffects of the LHPP gene polymorphism on the functional and structural changes of gray matter in major depressive disorder
Author(s) -
Lingling Cui,
Fei Wang,
Yin Zhang,
Miao Chang,
Yumeng Song,
Yange Wei,
Jing Lv,
Yifan Zhang,
Yanqing Tang,
Xiaohong Gong,
Ke Xu
Publication year - 2020
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.12.01
Subject(s) - major depressive disorder , cuneus , dorsolateral prefrontal cortex , anterior cingulate cortex , prefrontal cortex , posterior cingulate , single nucleotide polymorphism , temporal cortex , hippocampal formation , voxel based morphometry , neuroscience , medicine , genotype , psychology , white matter , cortex (anatomy) , biology , precuneus , functional magnetic resonance imaging , magnetic resonance imaging , genetics , cognition , gene , radiology
A single-nucleotide polymorphism (SNP) of the LHPP gene (rs35936514) has been reported to be associated with major depressive disorder (MDD) in genome-wide association studies. However, the systems-level neural effects of rs35936514 that mediate the association are unknown. We hypothesized that variations in rs35936514 would be associated with structural and functional changes in gray matter (GM) at rest in MDD patients.