Open AccessVoxel-wise Optimization of Pseudo Voigt Profile (VOPVP) for Z-spectra fitting in chemical exchange saturation transfer (CEST) MRI
Author(s) -
Lihong Zhang,
Yuyan Zhao,
Yanrong Chen,
Chongxue Bie,
Yuhua Liang,
Xiaowei He,
Xiaolei Song
Publication year - 2019
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.10.01
Subject(s) - spectral line , gaussian , nuclear magnetic resonance , voigt profile , voxel , saturation (graph theory) , magnetization transfer , physics , gaussian function , computational physics , bloch equations , chemistry , statistical physics , mathematics , magnetic resonance imaging , computer science , artificial intelligence , quantum mechanics , medicine , combinatorics , radiology
Chemical exchange saturation transfer (CEST) MRI is a promising approach for detecting biochemical alterations in cancers and neurological diseases, but the quantification can be challenging. Among numerous quantification methods, Lorentzian difference (LD) is relatively simple and widely used, which employs Lorentzian line-shape as a reference to describe the direct saturation (DS) of water and takes account of difference against experimental CEST spectra data. However, LD often overestimates CEST and nuclear overhauser enhancement (NOE) effects. Specifically, for fast-exchanging CEST species require higher saturation power (B 1_sat ) or in the presence of strong magnetization transfer (MT) contrast, Z-spectrum appears more like a Gaussian line-shape rather than a Lorentzian line-shape.