Open AccessHigh-frequency ultrasound deformation imaging for adult zebrafish during heart regeneration
Author(s) -
Chen Ho-Chiang,
HsienCheng Huang,
Chih Chung Huang
Publication year - 2020
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.09.20
Subject(s) - zebrafish , danio , regeneration (biology) , amputation , cardiac cycle , ultrasound , cardiology , cardiac function curve , medicine , human heart , cardiac muscle , biomedical engineering , anatomy , biology , microbiology and biotechnology , surgery , radiology , heart failure , biochemistry , gene
The adult human heart cannot efficiently generate new cardiac muscle cells in response to injury, and, therefore, cardiac injury results in irreversible damage to cardiac functions. The zebrafish ( Danio rerio ) is a crucial animal model in cardiac research because of its remarkable capacity for tissue regeneration. An adult zebrafish can completely regenerate cardiac tissue without a scar being formed, even after 20% of its ventricular myocardium has been resected. Zebrafish have been utilized in developmental biology and genetics research; however, the details of myocardium motions during their cardiac cycle in different regeneration phases are still not fully understood.