Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility | Zendy

Lin Yang | Zendy; Yu Xiao | Zendy; Ashley M. Fuller | Zendy; Melissa A. Troester | Zendy; Amy L. Oldenburg | Zendy

Open Access

Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility

Author(s) -

Lin Yang,

Yu Xiao,

Ashley M. Fuller,

Melissa A. Troester,

Amy L. Oldenburg

Publication year - 2019

Publication title -

quantitative imaging in medicine and surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 21

eISSN - 2223-4292

pISSN - 2223-4306

DOI - 10.21037/qims.2019.08.15

Subject(s) - organoid , motility , intracellular , chemistry , optical coherence tomography , microbiology and biotechnology , biophysics , biology , medicine , pathology , ophthalmology

An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models.

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