Open AccessImprovements in left ventricular regional and global systolic function following treatment with S100A4-shRNA after myocardial infarction in mice
Author(s) -
Qian Li,
Yanjuan Zhang,
Menglin Zhu,
Feng Xie,
Thomas R. Porter,
Di Xu
Publication year - 2019
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.05.25
Subject(s) - small hairpin rna , medicine , cardiology , myocardial infarction , trichrome stain , cardiac function curve , ligation , speckle tracking echocardiography , infarction , ultrasound , ejection fraction , immunohistochemistry , apoptosis , radiology , heart failure , biology , biochemistry , gene knockdown
S100A4 plays a vital role in cardiac fibrosis after myocardial infarction (MI), but its effects on myocardial mechanics and remodeling are unknown. We hypothesized that regional and global left ventricular (LV) systolic function as determined by speckle tracking echocardiography (STE) would be improved with inhibition of S100A4 using short hairpin (sh) RNA. This study aimed to investigate whether STE can delineate the efficacy and safety of S100A4-shRNA in MI.