Open AccessNeuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study
Author(s) -
Dong Zhang,
Lin Shi,
Xiubao Song,
Changzheng Shi,
Ping Sun,
Wutao Lou,
Defeng Wang,
Liangping Luo
Publication year - 2019
Publication title -
quantitative imaging in medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 21
eISSN - 2223-4292
pISSN - 2223-4306
DOI - 10.21037/qims.2019.05.18
Subject(s) - endophenotype , neuroimaging , insula , medicine , middle temporal gyrus , temporal lobe , neuroscience , psychology , psychiatry , functional magnetic resonance imaging , cognition , epilepsy
Type 2 diabetes mellitus (T2DM) is characterized by notable familial aggregation involving common variants of many genes, and its heritability leads to a high prevalence in the siblings of affected individuals compared with the general population. Endophenotypes are objective, heritable, quantitative traits that appear to reflect the genetic risk for polygenic disorders at more biologically tractable levels. Based on a sibling pair design, we aimed to find the neuroimaging endophenotypes of T2DM and investigate the role of inherent neurological disorders in the pathogenesis and deterioration of T2DM.