Open AccessMicroRNA regulation of CD8+ T cell responses
Author(s) -
John D. Gag,
K. Mark Ansel
Publication year - 2019
Publication title -
non-coding rna investigation
Language(s) - English
Resource type - Journals
ISSN - 2522-6673
DOI - 10.21037/ncri.2019.07.02
Subject(s) - microrna , biology , cd8 , regulation of gene expression , immune system , transcription factor , function (biology) , computational biology , gene , t cell , microbiology and biotechnology , genetics
MicroRNAs (miRNAs) are a class of short noncoding RNAs that play critical roles in the regulation of a broad range of biological processes. Like transcription factors, miRNAs exert their effects by modulating the expression of networks of genes that operate in common or convergent pathways. CD8 + T cells are critical agents of the adaptive immune system that provide protection from infection and cancer. Here, we review the important roles of miRNAs in the regulation of CD8 + T cell biology and provide perspectives on the broader emerging principles of miRNA function.