Open AccessClinical importance of Bcl-2-like 11 deletion polymorphism in idiopathic pulmonary fibrosis
Author(s) -
Kazutoshi Isobe,
Takuma Issiki,
Susumu Sakamoto,
Go Sano,
Yujiro Takai,
Naobumi Tochigi,
Sakae Homma
Publication year - 2019
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2019.07.25
Subject(s) - idiopathic pulmonary fibrosis , medicine , exacerbation , gastroenterology , glutathione , fibrosis , pulmonary function testing , genotype , pathology , lung , biology , gene , genetics , biochemistry , enzyme
Reactive oxygen species (ROS) can play a role in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) by contributing to epithelial damage. Bcl-2-like 11 ( BIM ) is involved in the generation of ROS via forkhead box O3 (FOXO3), and a BIM deletion polymorphism related to apoptosis has been reported to be specific to Asians. Here we examine the clinical features of IPF in patients with BIM deletion polymorphism.