Open AccessParticulate matter disrupts airway epithelial barrier via oxidative stress to promote Pseudomonas aeruginosa infection
Author(s) -
Jinguo Liu,
Xiaoyan Chen,
Maosen Dou,
Hong He,
Mohan Ju,
Shimeng Ji,
Ji Zhou,
Cuicui Chen,
Donghui Zhang,
Changhong Miao,
Yuanlin Song
Publication year - 2019
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2019.05.77
Subject(s) - microbiology and biotechnology , oxidative stress , western blot , reactive oxygen species , flow cytometry , bacteria , pseudomonas aeruginosa , respiratory epithelium , in vivo , tight junction , viability assay , intracellular , chemistry , cell , biology , respiratory system , immunology , biochemistry , genetics , anatomy , gene
Airborne particulate matter (PM) is associated with increasing susceptibility to respiratory bacterial infection. Tight junctions (TJs) are protein complexes that form airway epithelial barrier against infection. This study aimed to investigate the effects of PM on the airway TJs in response to infection.