Open AccessDeep targeted sequencing analysis of hot spot mutations in non-small cell lung cancer patients from the Middle Eastern population
Author(s) -
Pierre Khoueiry,
Ghina Fakhri,
Reem Akel,
Majd El Assaad,
Rami Mahfouz,
Fadlo R. Khuri,
Hassan Chami,
Jason L. Petersen,
Sarah Viet,
Gareth E. Davies,
Humam Kadara,
Arafat Tfayli
Publication year - 2019
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2019.05.74
Subject(s) - kras , stk11 , medicine , lung cancer , amplicon , deep sequencing , targeted therapy , dna sequencing , cold pcr , adenocarcinoma , cdkn2a , ros1 , oncology , population , mutation , cancer , gene , genetics , biology , colorectal cancer , point mutation , polymerase chain reaction , genome , environmental health
The overall 5-year survival of lung cancer remains dismal despite the current treatment regimens. Testing for driver mutations has become routine practice for oncologists due to the presence of targeted therapy readily available for patients. Deep targeted sequencing through next generation sequencing (NGS) is an adequate methodology to detect mutations at multi-genetic levels. The molecular pathology of non-small cell lung cancer (NSCLC) is poorly understood in the Middle East and, to date, no other reports have been published on deep targeted sequencing of lung adenocarcinoma (LUAD) tissues.