Correlation between thyroid transcription factor-1 expression, immune-related thyroid dysfunction, and efficacy of anti-programmed cell death protein-1 treatment in non-small cell lung cancer | Zendy

Junji Koyama | Zendy; Atsushi Horiike | Zendy; Takahiro Yoshizawa | Zendy; Yosuke Dotsu | Zendy; Ryo Ariyasu | Zendy; Masafumi Saiki | Zendy; Tomoaki Sonoda | Zendy; Ken Uchibori | Zendy; Shingo Nishikawa | Zendy; Satoru Kitazono | Zendy; Noriko Yanagitani | Zendy; Hironori Ninomiya | Zendy; Yuichi Ishikawa | Zendy; Makoto Nishio | Zendy

Open Access

Correlation between thyroid transcription factor-1 expression, immune-related thyroid dysfunction, and efficacy of anti-programmed cell death protein-1 treatment in non-small cell lung cancer

Author(s) -

Junji Koyama,

Atsushi Horiike,

Takahiro Yoshizawa,

Yosuke Dotsu,

Ryo Ariyasu,

Masafumi Saiki,

Tomoaki Sonoda,

Ken Uchibori,

Shingo Nishikawa,

Satoru Kitazono,

Noriko Yanagitani,

Hironori Ninomiya,

Yuichi Ishikawa,

Makoto Nishio

Publication year - 2019

Publication title -

journal of thoracic disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2019.04.102

Subject(s) - medicine , thyroid , thyroid transcription factor 1 , immune system , transcription factor , lung cancer , cancer research , thyroid cancer , lung , protein expression , cell , programmed cell death , oncology , thyroid dysfunction , pathology , immunology , cancer , apoptosis , gene , adenocarcinoma , biology , biochemistry , genetics

Recent studies have suggested a correlation between immune-related thyroid dysfunction (irTD) and the superior efficacy of anti-programmed cell death protein-1 (anti-PD-1) treatment in non-small cell lung cancer (NSCLC). Embryologically, the lung and thyroid are similar in origin, and thyroid transcription factor-1 (TTF-1) expresses in both organs, including NSCLC. We explored our hypothesis that TTF-1 expression in NSCLC might correlate with irTD incidence and anti-PD-1 treatment efficacy.

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