Open AccessCellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease
Author(s) -
Ryo Okuda,
Kazutetsu Aoshiba,
Hidekazu Matsushima,
Takashi Ogura,
Koji Okihara,
Kenichi Ohashi
Publication year - 2019
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2019.02.11
Subject(s) - senescence , medicine , idiopathic pulmonary fibrosis , immunostaining , copd , interstitial lung disease , pathology , lung , connective tissue disease , connective tissue , pulmonary fibrosis , lung cancer , fibrosis , immunohistochemistry , disease , autoimmune disease
The senescence-associated secretory phenotype (SASP) develops due to cellular senescence during conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). However, studies comparing the degree of cellular senescence and SASP between COPD and IPF are limited. Furthermore, to the best of our knowledge, no study has examined cellular senescence and/or SASP in connective tissue disease-associated interstitial lung disease (CTD-ILD).