Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D | Zendy

Shi Sheng | Zendy; Jiacheng Sun | Zendy; Qingyou Meng | Zendy; Yunsheng Yu | Zendy; Haoyue Huang | Zendy; Teng Ma | Zendy; Ziying Yang | Zendy; Xuan Liu | Zendy; Junjie Yang | Zendy; Zhenya Shen | Zendy

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Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D

Author(s) -

Shi Sheng,

Jiacheng Sun,

Qingyou Meng,

Yunsheng Yu,

Haoyue Huang,

Teng Ma,

Ziying Yang,

Xuan Liu,

Junjie Yang,

Zhenya Shen

Publication year - 2018

Publication title -

journal of thoracic disease

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 60

eISSN - 2077-6624

pISSN - 2072-1439

DOI - 10.21037/jtd.2018.09.50

Subject(s) - vascular endothelial growth factor , matrigel , angiogenesis , mesenchymal stem cell , sonic hedgehog , patched , hepatocyte growth factor , microbiology and biotechnology , smoothened , growth factor , bone marrow , cd31 , vascular endothelial growth factor a , biology , hedgehog signaling pathway , cancer research , medicine , immunology , signal transduction , receptor , vegf receptors

Bone marrow-derived mesenchymal stem cells (BMSCs) have been proved to be capable of differentiating into endothelial cells (ECs), however, the differentiation efficiency is rather low. Sonic hedgehog (Shh), an important factor in vascular development and postnatal angiogenesis, exerted promotional effect on new vessel formation in the ischemic animal models. Therefore, the current study aims to investigate whether Shh could induce the endothelial differentiation of BMSCs both in vitro and in vivo , as well as the mechanism of differentiation induction.

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