Open AccessSonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D
Author(s) -
Shi Sheng,
Jiacheng Sun,
Qingguo Meng,
Yunsheng Yang,
Haoyue Huang,
Teng Ma,
Yangxin Li,
Xuan Liu,
Zhenya Shen
Publication year - 2018
Publication title -
journal of thoracic disease
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2018.09.50
Subject(s) - vascular endothelial growth factor , matrigel , angiogenesis , mesenchymal stem cell , sonic hedgehog , patched , hepatocyte growth factor , microbiology and biotechnology , smoothened , growth factor , bone marrow , cd31 , vascular endothelial growth factor a , biology , hedgehog signaling pathway , cancer research , medicine , immunology , signal transduction , receptor , vegf receptors
Bone marrow-derived mesenchymal stem cells (BMSCs) have been proved to be capable of differentiating into endothelial cells (ECs), however, the differentiation efficiency is rather low. Sonic hedgehog (Shh), an important factor in vascular development and postnatal angiogenesis, exerted promotional effect on new vessel formation in the ischemic animal models. Therefore, the current study aims to investigate whether Shh could induce the endothelial differentiation of BMSCs both in vitro and in vivo , as well as the mechanism of differentiation induction.