Open AccessSerum decorin is a potential prognostic biomarker in patients with acute exacerbation of idiopathic pulmonary fibrosis
Author(s) -
Takefumi Nikaido,
Yoshinori Tanino,
Xintao Wang,
Yuki Sato,
Ryuichi Togawa,
Masami Kikuchi,
Kenichi Misa,
Kazue Saito,
Naoko Fukuhara,
Takaya Kawamata,
Mami Rikimaru,
Takashi Umeda,
Julia Morimoto,
Tatsuhiko Koizumi,
Yasuhito Suzuki,
Kenichiro Hirai,
Manabu Uematsu,
Hiroyuki Minemura,
Atsuro Fukuhara,
Suguru Sato,
Junpei Saito,
Hiroshi Yokouchi,
Kenya Kanazawa,
Yoko Shibata
Publication year - 2018
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2018.08.60
Subject(s) - decorin , medicine , idiopathic pulmonary fibrosis , exacerbation , pulmonary fibrosis , idiopathic interstitial pneumonia , gastroenterology , biomarker , usual interstitial pneumonia , pathology , fibrosis , lung , proteoglycan , biology , cartilage , biochemistry , anatomy
Decorin is a small leucine-rich repeat proteoglycan that plays a critical role in collagen fibrillogenesis, and regulates inflammation, wound healing and angiogenesis. In idiopathic pulmonary fibrosis (IPF), decorin is expressed in fibrotic lesions; furthermore, intratracheal gene transfer of decorin has been demonstrated to inhibit bleomycin-induced pulmonary fibrosis. Although these results suggest the critical role of decorin in pulmonary fibrosis, the role of decorin in the acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) has not been clarified in detail. Thus, the goal of this study was to determine the role of decorin in AE-IIP.