Open AccessRegulatory T cells may play a protection role in postoperative pulmonary dysfunction in rheumatic heart disease
Author(s) -
Xiaoyang Zhang,
Lin Zhou,
Zhen Guo,
Ye Kong,
Wei Zhang,
Liming Lu,
Xin Li
Publication year - 2018
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2018.05.71
Subject(s) - medicine , cardiopulmonary bypass , flow cytometry , immune system , lymphocyte , immunology , heart disease , disease , population , environmental health
Postoperative pulmonary dysfunction (PPD) is a common complication observed in patients after cardiac surgery with cardiopulmonary bypass (CPB). The underlying mechanism regulating lung injury after CPB is unclear. However, since the involvement of regulatory T (Treg) cells and T helper 17 (Th17) cells in immune responses has been well established, in this study, we investigated the contribution of these lymphocyte subsets to the development of PPD after CPB.