Open AccessAltered expression of TIAM1 in endotoxin-challenged airway epithelial cells and rodent septic models
Author(s) -
Jie Ma,
Chuanxi Chen,
Yongjun Liu,
Mahendra Damarla,
Becky M. Vonakis,
Xiangdong Guan,
Li Gao
Publication year - 2018
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2018.05.192
Subject(s) - sepsis , cytoskeleton , lipopolysaccharide , actin cytoskeleton , actin , medicine , pathogenesis , inflammation , immunology , gene expression , epithelium , microbiology and biotechnology , cancer research , pathology , biology , gene , cell , genetics
In sepsis, reorganization of the actin cytoskeleton in the epithelium during inflammation will lead to a breakdown of epithelial barrier integrity, and contribute to the pathogenesis of sepsis, but the exact changes of various components regulating the actin cytoskeleton pathway remain unclear.