Open AccessScreening for early stage lung cancer and its correlation with lung nodule detection
Author(s) -
Fangfei Qian,
Weiguang Yang,
Qunhui Chen,
Xueyan Zhang,
Baohui Han
Publication year - 2018
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2017.12.123
Subject(s) - medicine , lung cancer , lung cancer screening , national lung screening trial , lung , nodule (geology) , stage (stratigraphy) , radiology , cancer , population , disease , treatment of lung cancer , oncology , intensive care medicine , environmental health , paleontology , biology
Currently, the most effective way of reducing lung cancer mortality is early diagnosis of lung cancer. The National Lung Screening Trial has proved the efficacy of lung cancer screening using low-dose computed tomography to reduce lung cancer mortality. However, many questions remain surrounding lung cancer screening implementation, among which include how to select the optimal risk population, the personalized screening interval based different levels of risk, methods to improve diagnostic discrimination between malignant and benign disease in detected lung nodules, and the roles of biomolecular markers in stratifying risk and in guiding the management of indeterminate nodules. This review concentrates on the latest developments of lung cancer screening and provides an overview of the main unanswered questions on lung nodule detection.