Open AccessDoxycycline attenuates paraquat-induced pulmonary fibrosis by downregulating the TGF-β signaling pathway
Author(s) -
Xu-Fang Hua,
Xiaohe Li,
Mi-Mi Li,
Chengyu Zhang,
Huijuan Liu,
Tao Sun,
Cheng Yang
Publication year - 2017
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2017.10.42
Subject(s) - pulmonary fibrosis , doxycycline , paraquat , medicine , pharmacology , lung , inflammation , fibrosis , immunohistochemistry , transforming growth factor , signal transduction , epithelial–mesenchymal transition , cancer research , pathology , immunology , cancer , biology , microbiology and biotechnology , biochemistry , antibiotics , metastasis
Paraquat (PQ) is a highly efficient herbicide that remains widely used in agriculture. However, the inappropriate application of this herbicide may cause multiple organ injuries including pulmonary injury. In this study, we report that doxycycline (Doxy) treats PQ-induced pulmonary fibrosis (PF).