Open AccessUrban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway
Author(s) -
Jian Wang,
Jian-An Huang,
Linlin Wang,
Cuicui Chen,
Dong Yang,
Meiling Jin,
Chunxue Bai,
Yuanlin Song
Publication year - 2017
Publication title -
journal of thoracic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 60
eISSN - 2077-6624
pISSN - 2072-1439
DOI - 10.21037/jtd.2017.09.135
Subject(s) - mapk/erk pathway , proinflammatory cytokine , inflammation , bronchoalveolar lavage , p38 mitogen activated protein kinases , nf κb , reactive oxygen species , signal transduction , medicine , oxidative stress , immunology , pharmacology , chemistry , microbiology and biotechnology , lung , biology
Particulate matter (PM) is a high risk factor for various respiratory diseases and triggers an inflammatory response in lung tissues. However, the molecular mechanism of the PM-induced inflammatory response is incompletely understood.