Open AccessIdentification of potential biomarkers and pathways in ulcerative colitis with combined public mRNA and miRNA expression microarray data analysis
Author(s) -
Lili Yang,
Yaoyao Bian,
Zhengjun Li,
Yan Yan,
Junyi Li,
Wenlin Li,
Li Zeng
Publication year - 2019
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2019.06.06
Subject(s) - microrna , microarray , microarray analysis techniques , mmp1 , gene , gene expression , dna microarray , computational biology , gene expression profiling , regulation of gene expression , bioinformatics , biology , medicine , genetics
Ulcerative colitis (UC) is a chronic, relapsing and non-specific inflammatory disease, involving various genes and pathways in their pathogenesis. Increasing evidences have showed that microRNAs (miRNAs) act as key post-transcriptional regulators of gene expression in UC. This current study aimed to identify key miRNAs, potential target genes, and relevant pathways involved in UC to uncover their underlying molecular mechanisms by using bioinformatics analysis.