Open AccessInflammatory response and optimalisation of perioperative fluid administration during hyperthermic intraoperative intraperitoneal chemotherapy surgery
Author(s) -
Piet de Witte,
Christien A. de Witt,
Johan L. van de Minkelis,
Djamila Boerma,
H. Frank Solinger,
C. E. Hack,
Peter Bruins
Publication year - 2019
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2018.12.09
Subject(s) - medicine , perioperative , hyperthermic intraperitoneal chemotherapy , intraperitoneal chemotherapy , surgery , anesthesia , cytoreductive surgery , cancer , ovarian cancer
Surgical cytoreduction and simultaneous hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis has a high incidence of postoperative complications. Inadequate intraoperative volume therapy is a known risk factor for the development of postoperative complications. Another possible risk factor is the inflammatory response due to surgery and HIPEC. The aim of this observational pilot study was to monitor fluid intake in the first 24 hours peri- and postoperative by using a non-invasive cardiac output indicator. Furthermore, we measured circulating cytokines and evaluated the possible relation of these changes of inflammatory response with the non-invasive monitored fluid management.