Open AccessThe platelets-neutrophils to lymphocytes ratio: a new prognostic marker in metastatic colorectal cancer
Author(s) -
Joey Mercier,
Ioannis A. Voutsadakis
Publication year - 2018
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2018.03.13
Subject(s) - medicine , colorectal cancer , hazard ratio , neutrophilia , neutrophil to lymphocyte ratio , thrombocytosis , proportional hazards model , lymphocytopenia , oncology , cancer , gastroenterology , univariate analysis , platelet , multivariate analysis , lymphocyte , confidence interval
The cancer micro-environment is recognized as having an increasing importance in cancer progression. Immune cells originating from the peripheral blood are important elements of this environment. Thrombocytosis, neutrophilia and lymphocytopenia have been found to be negative prognostic indicators in many cancers. This study aims to evaluate the potential of the use of a novel hematological marker, the platelet-neutrophil to lymphocyte ratio (PNLR) as a practical, reliable, and inexpensive prognostic tool in metastatic colorectal adenocarcinomas.