Open AccessImmune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy
Author(s) -
Chongkai Wang,
Jun Gong,
Travis Y. Tu,
Peter P. Lee,
Marwan Fakih
Publication year - 2018
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2018.01.09
Subject(s) - microsatellite instability , medicine , colorectal cancer , tumor infiltrating lymphocytes , immune checkpoint , pd l1 , foxp3 , cd8 , tumor microenvironment , cancer research , immune system , blockade , immunohistochemistry , oncology , immunotherapy , immunology , cancer , biology , receptor , allele , microsatellite , gene , biochemistry
Microsatellite instability-high (MSI-H) and polymerase ε ( POLE )-mutated metastatic colorectal cancer (mCRC) represent hypermutated and ultramutated tumor phenotypes, respectively, that may predict benefit to checkpoint blockade [anti-programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1)].