Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy | Zendy

Chongkai Wang | Zendy; Jun Gong | Zendy; Travis Y. Tu | Zendy; Peter P. Lee | Zendy; Marwan Fakih | Zendy

Open Access

Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy

Author(s) -

Chongkai Wang,

Jun Gong,

Travis Y. Tu,

Peter P. Lee,

Marwan Fakih

Publication year - 2018

Publication title -

journal of gastrointestinal oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.084

H-Index - 39

eISSN - 2219-679X

pISSN - 2078-6891

DOI - 10.21037/jgo.2018.01.09

Subject(s) - microsatellite instability , medicine , colorectal cancer , tumor infiltrating lymphocytes , immune checkpoint , pd l1 , foxp3 , cd8 , tumor microenvironment , cancer research , immune system , blockade , immunohistochemistry , oncology , immunotherapy , immunology , cancer , biology , receptor , allele , microsatellite , gene , biochemistry

Microsatellite instability-high (MSI-H) and polymerase ε ( POLE )-mutated metastatic colorectal cancer (mCRC) represent hypermutated and ultramutated tumor phenotypes, respectively, that may predict benefit to checkpoint blockade [anti-programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1)].

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