Open AccessOxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy
Author(s) -
G. Le Baut,
Jean-Marc Guilloit,
Vincent Leprince,
Yann Ollivier,
Catherine Dubos-Arvis,
Pascal Dô,
Jasmine Sutter,
Ludovic Loge,
Radj Gervais
Publication year - 2018
Publication title -
journal of gastrointestinal oncology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2018.01.01
Subject(s) - medicine , oxaliplatin , pneumonitis , pneumonia , bronchiolitis obliterans , chemotherapy , irinotecan , colorectal cancer , cancer , lung , lung transplantation
Oxaliplatin given systemically is associated with pneumonitis in less than 1% of cases. This case report describes acute respiratory failure, due to bronchiolitis organising pneumonia, in a patient with colorectal carcinoma being treated with hyperthermic intraperitoneal chemotherapy which included oxaliplatin and CPT-11 (irinotecan). The clinical course, the lack of an identifiable infectious agent and the complete response to corticosteroids suggested a drug-induced cause. After ruling out CPT-11, oxaliplatin was considered to be the causal agent. The unusual feature of this case was that pneumonitis developed after intraperitoneal administration of oxaliplatin. Oxaliplatin-associated respiratory complications can occur whatever route the drug is administered.