Open AccessSingle nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site of COX gene is a strong colorectal cancer determinant
Author(s) -
Meysam Mosallaei,
Miganoosh Simonian,
Fateme Ahangari,
Maryam Miraghajani,
Deniz Mortazavi,
Ahmad Salehi,
Sharifeh Khosravi,
Roya Salehi
Publication year - 2018
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2017.11.01
Subject(s) - single nucleotide polymorphism , genotype , medicine , odds ratio , colorectal cancer , oncology , population , bioinformatics , genetics , cancer , gene , biology , environmental health
Genetic determinants are considered as driving forces in development colorectal cancer (CRC), a malignancy that ranks as the second cause of cancer death in the world. Single nucleotide polymorphisms (SNPs), are considered as the main genetic factor in cancers susceptibility. MicroRNAs are critical players in posttranslational gene regulation by binding to their specific recognition sequences located at 3' untranslated region (UTR) of mRNAs. In present study we have elucidated the role of 9,850 A > G (rs4648298), in development of sporadic CRC in Iranian population.