Open AccessMolecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern
Author(s) -
Humaid O. AlShamsi,
Jeremy C. Jones,
Yazan Fahmawi,
Ibrahim Dahbour,
Aziz Tabash,
Reham Abdel-Wahab,
Ahmed Abousamra,
Kenna Shaw,
Lianchun Xiao,
Manal M. Hassan,
Benjamin R. Kipp,
Scott Kopetz,
Amr S. Soliman,
Robert R. McWilliams,
Robert A. Wolff
Publication year - 2016
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo.2016.11.02
Subject(s) - kras , neuroblastoma ras viral oncogene homolog , medicine , oncology , colorectal cancer , population , germline mutation , exact test , adenocarcinoma , cancer , mutation , gene , genetics , biology , environmental health
The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in colorectal cancer (CRC) differ among populations. The aim of this study was to assess mutation frequencies in the Arab population and determine their correlations with certain clinicopathological features.